Trial and cure-program status families can track.
Built from ClinicalTrials.gov status on programs we watch. Type1Cure never implies you are eligible — talk with your care team before any trial decision.
Programs with recruiting activity
From the live cure pipeline (8 programs tracked). Always verify on the registry page.
Zimislecel (VX-880)
This is one of the most advanced cell-replacement programs and has reported trial participants reducing or eliminating injected insulin. It still depends on lifelong immunosuppression, which is the trade-off researchers are now trying to remove.
VX-264 (encapsulated islet cells)
If an encapsulation device can keep islet cells alive without immunosuppression, it removes the biggest barrier to making cell-replacement a practical option for most people with type 1 diabetes.
Cell Pouch islet transplant
A durable, retrievable implant site is a key piece of the cell-therapy puzzle, and is being combined with newer approaches to reduce or remove immunosuppression.
Recent trial feed items
Pediatric Artificial Intelligence for Retinopathy Screening in Children With Type 1 Diabetes
RECRUITING, NA. Interventions: Non-mydriatic fundus camera photography, Fundus ophtalmoscopy, Optic coherence tomography. Locations: Prague, Prague 5, Czechia. The proposed project is a clinical intervention trial testing the feasibility and effectiveness of diabetic retinopathy screening evaluated by artificial intelligence (AI) based software in children with type 1 diabetes (CwD). Another novel method, the confocal microscopy of the retina will be used...
A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes
RECRUITING, PHASE3. Interventions: VX-880. Locations: Duarte, California, United States | San Francisco, California, United States | Miami, Florida, United States. This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
China Diabetes Type 1 Study (CD1S) by China Alliance for Type 1 Diabetes
RECRUITING. Interventions: Standard type 1 diabetes management model constructed by China Alliance for Type 1 Diabetes in each center. Locations: Lanzhou, Gansu, China | Shenzhen, Guangdong, China | Haikou, Hainan, China. The aim of the China Diabetes Type 1 Study (CD1S) is to conduct a nationwide type 1 diabetes (T1D) registry study in patients with T1D and in pediatric adolescent patients with diabetes who had an age of onset \<= 20 years. CD1S compromi...
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
RECRUITING, NA. Interventions: Tandem t:slim X2 with Control-IQ Technology, Sensor augmented pump (SAP) therapy. Locations: Charlottesville, Virginia, United States. This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes. AP technology is a system of devices that closely mimics the glucose-regulating function of a healthy human pancreas. It includes an insulin pump and a conti...
Effects of Circadian Rhythm on Glycemic Regulation During Continuous Moderate Exercise and Intense Intermittent Disease in Adolescents Living With Type 1 Diabetes
RECRUITING, NA. Interventions: physical test. Locations: Loos, Nord, France. Interventional research with minimal risks and constraints on the effects of circadian rhythm on glycemic regulation during intense moderate, continuous and intermittent exercise in adolescents living with type 1 diabetes
Effect of Ear Massage on Stress, Anxiety, and Sleep Quality in Parents of Children With Type 1 Diabetes
RECRUITING, NA. Interventions: Effective Ear Massage, Sham Ear Massage. Locations: Mersin, Turkey (Türkiye). The purpose of this clinical trial is to determine the effect of self-administered ear massage on stress, anxiety levels, and sleep quality in parents of children diagnosed with Type 1 diabetes. Additionally, it aims to assess whether ear massage can prevent stress, anxiety, and poor sleep quality. The primary questions it seeks to answer are: H0:...
Association Between Sarcopenia And Diabetic Neuropathy In Adults With Type 1 Diabetes, A Pilot Study
RECRUITING, NA. Interventions: Dual energy X-ray absorptiometry. Locations: Rome, Lazio, Italy. Monocentric interventional prospective study to evaluate the prevalence of sarcopenia in adults with type 1 diabetes (T1DM) and to evaluate the association between diabetic neuropathy and sarcopenia in subjects with T1DM; to evaluate the prevalence of dynapenia in adults with T1DM and its association with diabetic neuropathy.
Continuous Ketone Monitoring in People With Type 1 Diabetes Using SGLT2 Inhibitors
RECRUITING, PHASE1. Interventions: SGLT-2 inhibitor. Locations: Montreal, Quebec, Canada. Type 1 diabetes is an autoimmune disease where the body attacks the insulin-producing cells in the pancreas. In the absence of insulin, the body is unable to effectively use glucose for energy, resulting in high blood sugar levels. This leads to a lifelong need for intensive insulin therapy to manage blood sugar and prevent complications arising from elevated blood g...
Also on the tracker
- Hypoimmune islet cells (UP421 / SC451)First-in-human / early research
- Tegoprubart (immune protection)Clinical trial
- Teplizumab (Tzield)FDA approved (delays onset)
- KRIYA-839 gene therapyPreclinical
- Gene-edited cell replacementEarly research
These are research programs pursuing a functional cure or disease modification for type 1 diabetes. None is a confirmed, broadly available cure. Trial status is informational, not medical advice, and not a recruiting offer. Verify eligibility and details with the official trial record and a clinician.