Early clinical trial/clinical trial/Vertex Pharmaceuticals

VX-264 (encapsulated islet cells)

If an encapsulation device can keep islet cells alive without immunosuppression, it removes the biggest barrier to making cell-replacement a practical option for most people with type 1 diabetes.

How it works

The same stem cell-derived islet cells are placed inside a small implantable device intended to shield them from the immune system, with the goal of avoiding immune-suppressing drugs entirely.

Approach

Encapsulated stem cell-derived islet cells

Immunosuppression

Designed to avoid immunosuppression

Live trial status

NCT05791201ACTIVE NOT RECRUITING

A Safety, Tolerability, and Efficacy Study of VX-264 in Participants With Type 1 Diabetes

Phase: PHASE1, PHASE2Enrollment: 7Updated: Jun 3, 2026

Open ClinicalTrials.gov record

These are research programs pursuing a functional cure or disease modification for type 1 diabetes. None is a confirmed, broadly available cure. Trial status is informational, not medical advice, and not a recruiting offer. Verify eligibility and details with the official trial record and a clinician.

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