Every serious program working toward a functional cure or disease modification, from stem cell-derived islets to immune protection and gene therapy. Each one is evidence-labeled and linked to its live clinical trial status, so you can tell real progress from a press release.
These are research programs pursuing a functional cure or disease modification for type 1 diabetes. None is a confirmed, broadly available cure. Trial status is informational, not medical advice, and not a recruiting offer. Verify eligibility and details with the official trial record and a clinician.
An infused antibody that quiets the immune attack on insulin-producing cells. It is FDA-approved to delay the onset of Stage 3 (clinical) type 1 diabetes in eligible at-risk people who are already in Stage 2.
An implanted 'Cell Pouch' is allowed to grow its own blood supply, then donor islet cells are placed inside it to produce insulin in a protected, vascularized site.
An antibody that calms a specific immune signal (CD40 ligand), studied as a gentler way to protect transplanted islet cells than today's standard immune-suppressing regimens.
Fully differentiated, insulin-producing islet cells made from stem cells are infused into the liver's portal vein. Because the cells are donor-derived, recipients take immune-suppressing medicine to protect them.
The same stem cell-derived islet cells are placed inside a small implantable device intended to shield them from the immune system, with the goal of avoiding immune-suppressing drugs entirely.
Uses gene editing to create insulin-producing cells engineered to hide from the immune system, with the goal of transplanting them without immune-suppressing drugs.
Islet cells are genetically engineered to evade the immune system (a 'hypoimmune' design), aiming to transplant them without immune-suppressing drugs. SC451 extends the idea to stem cell-derived islets.
A gene therapy program aiming to restore insulin production or immune balance through a single treatment. Still in preclinical development.
Some links below are affiliate links. If you buy through them, Type1Cure may earn a small commission at no extra cost to you. Affiliate relationships never affect our research coverage, evidence labels, rankings, or safety alerts.
We email when a tracked program posts new trial status, results, or a regulatory move. No hype, evidence-labeled.
Join the alert list