FDA approved (delays onset)/regulatory/Sanofi (developed by Provention Bio)

Teplizumab (Tzield)

This is the first therapy approved to change the course of type 1 diabetes by delaying it. Important: it delays onset for at-risk individuals; it is not a cure and does not reverse established diabetes.

How it works

An infused antibody that quiets the immune attack on insulin-producing cells. It is FDA-approved to delay the onset of Stage 3 (clinical) type 1 diabetes in eligible at-risk people who are already in Stage 2.

Approach

Anti-CD3 immunotherapy that delays onset

Immunosuppression

Short treatment course, not a transplant drug

Live trial status

NCT03875729COMPLETED

Recent-Onset Type 1 Diabetes Trial Evaluating Efficacy and Safety of Teplizumab

Phase: PHASE3Enrollment: 328Updated: Apr 23, 2024

Open ClinicalTrials.gov record

These are research programs pursuing a functional cure or disease modification for type 1 diabetes. None is a confirmed, broadly available cure. Trial status is informational, not medical advice, and not a recruiting offer. Verify eligibility and details with the official trial record and a clinician.

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