{ "schemaVersion": "1.0.0", "project": "Type1Cure.com", "generatedAt": "2026-06-11T19:15:35.302Z", "itemCount": 16, "medicalDisclaimer": "Preprints are not peer reviewed and early findings often change. This lane is for the earliest research signal, clearly labeled. It is information, not medical advice.", "sourceHealth": [ { "sourceId": "Breakthrough T1D", "sourceName": "Breakthrough T1D", "status": "ok", "itemCount": 10 }, { "sourceId": "medrxiv", "sourceName": "medrxiv", "status": "ok", "itemCount": 0 }, { "sourceId": "biorxiv", "sourceName": "biorxiv", "status": "ok", "itemCount": 6 }, { "sourceId": "EurekAlert", "sourceName": "EurekAlert", "status": "error", "itemCount": 0, "detail": "HTTP 404" } ], "items": [ { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/breakthrough-t1d-mourns-the-loss-of-william-v-tamborlane-m-d/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "Breakthrough T1D Mourns the Loss of William V. Tamborlane, M.D.", "url": "https://www.breakthrought1d.org/news-and-updates/breakthrough-t1d-mourns-the-loss-of-william-v-tamborlane-m-d/", "publishedAt": "2026-06-02T17:26:30.000Z", "category": "nonprofit", "summary": "Breakthrough T1D is deeply saddened at the passing of William V. Tamborlane, M.D. Dr. Tamborlane was a tireless champion for the type 1 diabetes (T1D) community, a pioneering clinical scientist, dedicated physician, and longtime Breakthrough T1D partner, grantee, reviewer, advisor, and friend. “Bill Tamborlane was a g…", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": false }, { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/type-1-diabetes-t1d-hurricanes-wildfires-heat-waves-power-outages-emergencies/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "Summer Emergencies with T1D: Navigating Heat Waves, Hurricanes, Wildfires, and Power Outages", "url": "https://www.breakthrought1d.org/news-and-updates/type-1-diabetes-t1d-hurricanes-wildfires-heat-waves-power-outages-emergencies/", "publishedAt": "2026-05-29T18:19:15.000Z", "category": "nonprofit", "summary": "It’s critical that in an emergency situation, people with T1D are prepared! Depending on where you live, common summer emergencies may include heat waves, hurricanes, wildfires, and power outages—sometimes all at once. Keeping Insulin Cool During a summer emergency, it’s important to keep your insulin cool as, like an…", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": false }, { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/afrezza-approved-t1d-children-adolescents/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "Afrezza Rapid-Acting Inhaled Insulin Approved for Children and Adolescents with T1D", "url": "https://www.breakthrought1d.org/news-and-updates/afrezza-approved-t1d-children-adolescents/", "publishedAt": "2026-05-29T16:43:12.000Z", "category": "nonprofit", "summary": "Afrezza, a rapid-acting, inhaled mealtime insulin, has been approved by the FDA for use in children and adolescents ages 6+ with T1D. The post Afrezza Rapid-Acting Inhaled Insulin Approved for Children and Adolescents with T1D appeared first on Breakthrough T1D .", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": false }, { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/aid-approved-for-pregnancy/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "First Automated Insulin Delivery System Approved for Pregnancy with Type 1 Diabetes", "url": "https://www.breakthrought1d.org/news-and-updates/aid-approved-for-pregnancy/", "publishedAt": "2026-05-29T13:12:09.000Z", "category": "nonprofit", "summary": "Tandem’s Control-IQ+ is the first-ever automated insulin delivery system cleared in the U.S. for pregnancy with type 1 diabetes. The post First Automated Insulin Delivery System Approved for Pregnancy with Type 1 Diabetes appeared first on Breakthrough T1D .", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": false }, { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/university-of-florida-nursing-alumni-breakthrough-t1d-walk-jacksonville/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "University of Florida Nursing Alumni Walk for T1D Cures in Jacksonville", "url": "https://www.breakthrought1d.org/news-and-updates/university-of-florida-nursing-alumni-breakthrough-t1d-walk-jacksonville/", "publishedAt": "2026-05-21T16:33:54.000Z", "category": "nonprofit", "summary": "On Saturday, May 2, the North Florida type 1 diabetes (T1D) community came together for Breakthrough T1D Walk, Jacksonville, raising more than $287,000 for T1D breakthroughs and cures! And $2,544 of that total was thanks to the University of Florida College of Nursing, which fielded an alumni Walk team for the event. …", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": true }, { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/its-that-time-of-year-adas-86th-scientific-sessions-are-coming-up/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "It’s that time of year: ADA’s 86th Scientific Sessions are coming up", "url": "https://www.breakthrought1d.org/news-and-updates/its-that-time-of-year-adas-86th-scientific-sessions-are-coming-up/", "publishedAt": "2026-05-15T13:00:00.000Z", "category": "nonprofit", "summary": "It’s that time of year again: the American Diabetes Association’s (ADA) 86th Scientific Sessions is taking place from June 5-8, 2026. Scientists, researchers, healthcare professionals, and industry leaders will travel to New Orleans, LA for the biggest annual diabetes conference in the world. Breakthrough T1D will be …", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": false }, { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/clinical-trial-participation-a-gilchrist-family-mission/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "Clinical Trial Participation: A Gilchrist Family Mission", "url": "https://www.breakthrought1d.org/news-and-updates/clinical-trial-participation-a-gilchrist-family-mission/", "publishedAt": "2026-05-12T13:00:00.000Z", "category": "nonprofit", "summary": "This article was written by Amanda Gilchrist, a Participant Advisory Council Member (PAC), a Clinical Trial Education Volunteer, and Breakthrough T1D supporter. Amanda’s story details her family’s type 1 diabetes (T1D) journey, why clinical trial participation is important to her, and her experience in the PAC. The vi…", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": false }, { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/international-experts-advance-clinical-adoption-of-islet-cell-therapies-at-breakthrough-t1d-hq/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "International Experts Advance Clinical Adoption of Islet Cell Therapies at Breakthrough T1D HQ", "url": "https://www.breakthrought1d.org/news-and-updates/international-experts-advance-clinical-adoption-of-islet-cell-therapies-at-breakthrough-t1d-hq/", "publishedAt": "2026-05-08T18:45:15.000Z", "category": "nonprofit", "summary": "Islet cell therapies for type 1 diabetes (T1D) replace destroyed insulin-producing beta cells with functional cells that allow the body to make insulin again. To ensure there are enough islet cells for everyone with T1D who wants them, Breakthrough T1D is prioritizing manufactured cell therapies, which can be made in …", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": true }, { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/an-interview-with-vertex/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "An Interview with Vertex", "url": "https://www.breakthrought1d.org/news-and-updates/an-interview-with-vertex/", "publishedAt": "2026-04-30T11:00:00.000Z", "category": "nonprofit", "summary": "It’s an exciting time for type 1 diabetes (T1D) research. Nearly every day, we’re seeing incredible progress across each area of Breakthrough T1D’s research portfolio to cure, prevent, and treat T1D and its complications. One area in particular is making headlines: Cell therapies.  I…", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": true }, { "id": "Breakthrough T1D:https://www.breakthrought1d.org/news-and-updates/mental-health-and-type-1-diabetes/", "source": "Breakthrough T1D", "sourceType": "nonprofit", "evidenceLabel": "nonprofit update", "title": "Balancing Mental Health and Type 1 Diabetes", "url": "https://www.breakthrought1d.org/news-and-updates/mental-health-and-type-1-diabetes/", "publishedAt": "2026-04-30T10:00:00.000Z", "category": "nonprofit", "summary": "Taking care of your mental health with type 1 diabetes is just as important as managing your blood sugar and taking your insulin. The post Balancing Mental Health and Type 1 Diabetes appeared first on Breakthrough T1D .", "tags": [ "nonprofit", "nonprofit" ], "cureSignal": false }, { "id": "biorxiv:10.64898/2026.04.23.720345", "source": "bioRxiv", "sourceType": "preprint", "evidenceLabel": "preprint (not peer reviewed)", "title": "High density culture of bovine embryonic stem cell derived mesenchymal cells on edible scaffolds for structured cultivated meat", "url": "https://www.biorxiv.org/content/10.64898/2026.04.23.720345", "publishedAt": "2026-04-27", "category": "cell biology", "summary": "Developing structured cultivated meat requires integrated solutions that combine scalable cell sources with edible, foodgrade materials capable of supporting highdensity growth and differentiation. Here, we evaluate bovine mesenchymal stem cells derived from embryonic stem cells (ESCderived iMSCs) as a scalable adipog…", "tags": [ "preprint", "research", "biorxiv" ], "cureSignal": true }, { "id": "biorxiv:10.64898/2026.04.25.720819", "source": "bioRxiv", "sourceType": "preprint", "evidenceLabel": "preprint (not peer reviewed)", "title": "Clinical grade cryopreservation unlocks transplant ready human pancreatic and stem cell derived islets for diabetes therapy", "url": "https://www.biorxiv.org/content/10.64898/2026.04.25.720819", "publishedAt": "2026-04-27", "category": "cell biology", "summary": "Pancreatic islet transplantation can restore endogenous insulin production and offers a potential cure for diabetes, but its clinical impact has been limited by the inability to preserve large numbers of functional islets for timely use. Cryopreservation could provide an on-demand supply, yet conventional methods caus…", "tags": [ "preprint", "research", "biorxiv" ], "cureSignal": true }, { "id": "biorxiv:10.64898/2026.04.24.720612", "source": "bioRxiv", "sourceType": "preprint", "evidenceLabel": "preprint (not peer reviewed)", "title": "Aquarius RNA helicase Protects Pluripotent Stem Cell Identity", "url": "https://www.biorxiv.org/content/10.64898/2026.04.24.720612", "publishedAt": "2026-04-27", "category": "cell biology", "summary": "Pluripotent stem cells must reconcile rapid replication with a highly dynamic transcriptional program, creating an inherent susceptibility to transcription-replication conflicts (TRCs). We demonstrate that embryonic stem cells (ESCs) operate in a \"resilient\" replication mode, tolerating high genomic traffic through th…", "tags": [ "preprint", "research", "biorxiv" ], "cureSignal": true }, { "id": "biorxiv:10.64898/2026.04.23.720410", "source": "bioRxiv", "sourceType": "preprint", "evidenceLabel": "preprint (not peer reviewed)", "title": "Microbiome-derived hydroxyphenyl propanoates enhance antitumour immunity by potentiating gasdermin D activity in tumour-associated myeloid cells", "url": "https://www.biorxiv.org/content/10.64898/2026.04.23.720410", "publishedAt": "2026-04-27", "category": "cancer biology", "summary": "The microbiome plays a critical role in immune health and response to immune-stimulating treatments, including cancer immunotherapy. However, the molecular mechanisms by which commensal microbes influence cancer immunology remain poorly understood. Here, we report a class of microbiome-derived metabolites called hydro…", "tags": [ "preprint", "research", "biorxiv" ], "cureSignal": false }, { "id": "biorxiv:10.64898/2026.04.23.720316", "source": "bioRxiv", "sourceType": "preprint", "evidenceLabel": "preprint (not peer reviewed)", "title": "CD180 identifies chemoresistant stem-like blasts and reveals a KMT2A-driven vulnerability in acute myeloid leukaemia", "url": "https://www.biorxiv.org/content/10.64898/2026.04.23.720316", "publishedAt": "2026-04-27", "category": "cancer biology", "summary": "Relapse and chemoresistance remain major challenges in paediatric acute myeloid leukaemia (PAML), particularly in KMT2A-rearranged (KMT2A-r) subtypes where conventional markers such as CD34 are often absent, complicating measurable residual disease (MRD) detection. Leukaemia stem/regenerating cells (LSC/LRC) drive dis…", "tags": [ "preprint", "research", "biorxiv" ], "cureSignal": false }, { "id": "biorxiv:10.64898/2026.04.23.720314", "source": "bioRxiv", "sourceType": "preprint", "evidenceLabel": "preprint (not peer reviewed)", "title": "Microfluidic bioprinting of a physiologically relevant thyroid three-dimensional in vitro model", "url": "https://www.biorxiv.org/content/10.64898/2026.04.23.720314", "publishedAt": "2026-04-27", "category": "bioengineering", "summary": "Endocrine disruptors (EDs) are an exogenous group of compounds associated with thyroid malfunctioning in the human body. Nonetheless, there are currently no adequate in vivo or in vitro models for the preclinical testing of these compounds since both animal and two-dimensional (2D) cell-based models are not able to mi…", "tags": [ "preprint", "research", "biorxiv" ], "cureSignal": false } ] }